Hello,

Yes, it is possible.

If the currency is different than the store’s designated currency, then the exchange rate needs to be available. The easiest way is to enable the fixer.io API in Wallets -> Exchange rates.

If the exchange rate is available and the user’s balance is sufficient to pay for the current cart, then the user will see an option to pay by that currency under “Bitcoin and Altcoin Wallets” on checkout.

with regards